Ladson is a census-designated place in Berkeley, Charleston and Dorchester counties in the U.S. state of South Carolina. The population was 13,790 at the 2010 census.Ladson is located in southwestern Berkeley County, northern Charleston County, and southeastern Dorchester County at 33°0′34″N 80°6′20″W / 33.00944°N 80.10556°W / 33.00944; -80.10556. It is bordered to the southwest by the town of Summerville, to the south by the city of North Charleston, to the east by the city of Goose Creek, and to the northwest by Sangaree, a census-designated place.U.S. Route 78 and Interstate 26 run parallel through Ladson, with Exit 203 providing access from I-26. Downtown Charleston is 20 miles to the southeast, and Columbia is 97 miles to the northwest.According to the United States Census Bureau, the CDP has a total area of 7.0 square miles, all land. This is a decrease from 8.6 square miles at the 2000 census, due to annexations of portions of the area into Summerville and North Charleston.